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Sensitive

Depression

near LINC02479 · rs35553410

Where this position leads

Condition: Endometriosis and Depression: Shared Genetics

rs35553410 Condition: Endometriosis and Depression: Shared Genetics Endometriosis and Depression: Share… Condition rs35553410 rs35553410 near LINC024…

What the study found

Who was studied 118,811 European ancestry cases, 327,427 European ancestry controls, 127,552 cases, 233,763 controls; replicated in 414,055 European ancestry cases, 892,299 European ancestry controls.

The effect Each copy of the C allele carried 1.02 times the odds of Depression (95% confidence interval 1.01-1.02); p = 2 × 10−10.

How common The C allele had a frequency of about 25% in the people studied.

Where it sits Chromosome 4, band 4q28.3 — between genes, 60 kb from LINC02479.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Depression compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Depression.
T/T Published research associates this genotype with typical/baseline likelihood of Depression — no copies of the reported risk allele.
Source
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard DM, Adams MJ, Clarke TK, Hafferty JD, Gibson J, Shirali M, Coleman JRI, Hagenaars SP, Ward J, Wigmore EM, Alloza C, Shen X
and 26 more — show all
Barbu MC, Xu EY, Whalley HC, Marioni RE, Porteous DJ, Davies G, Deary IJ, Hemani G, Berger K, Teismann H, Rawal R, Arolt V, Baune BT, Dannlowski U, Domschke K, Tian C, Hinds DA, Trzaskowski M, Byrne EM, Ripke S, Smith DJ, Sullivan PF, Wray NR, Breen G, Lewis CM, McIntosh AM
23andMe Research Team · Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Nature neuroscience · 2019 · PMID 30718901

Questions about rs35553410

What is rs35553410?

rs35553410 is a single position in the genome, in or near the near LINC02479 gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35553410 linked to?

On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.

Does having rs35553410 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35553410 come from?

GWAS Catalog, Nature neuroscience 2019, PMID:30718901. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depression (rs35553410). MyGeneLog™. https://www.mygenelog.com/variants/rs35553410

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