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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 21,758 European ancestry individuals; replicated in 9,173 individuals.
The effect
Each copy of the A allele shifted the measure 0.181 lower; p = 4 × 10−31.
How common The A allele had a frequency of about 87% in the people studied.
Where it sits Chromosome 2, band 2q33.1 — in an intron of CASP8.
What ClinVar records
ClassificationBenign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-08-25.
ClinVar record 1246892NM_001372051.1(CASP8):c.1305-268A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Caspase 8 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Caspase 8 levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Caspase 8 levels. This is the starting point the study compared everyone against.
rs35550815 is a single position in the genome, in or near the CASP8 gene. Published research associates it with caspase 8 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35550815 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35550815 come from?
GWAS Catalog, Nature metabolism 2020, PMID:33067605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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