LZTFL1 · rs35508621
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 8,461 African ancestry cases, 127,310 African ancestry controls, 10,109 Hispanic or Latin American cases, 75,831 Hispanic or Latin American controls, 2,047 East Asian ancestry cases, 19,113 East Asian ancestry controls, 97,783 European ancestry cases, 2,295,876 European ancestry controls, 1,103 Greater Middle Eastern (Middle Eastern, North African or Persian) cases, 15,818 Greater Middle Eastern (Middle Eastern, North African or Persian) controls, 6,081 South Asian ancestry cases, 41,399 South Asian ancestry controls.
The effect Each copy of the C allele carried 1.09 times the odds of SARS-CoV-2 infection (95% confidence interval 1.07-1.1); p = 9 × 10−30.
How common The C allele had a frequency of about 8% in the people studied.
Where it sits Chromosome 3, band 3p21.31 — in an intron of LZTFL1.
rs35508621 is a single position in the genome, in or near the LZTFL1 gene. Published research associates it with sars-cov-2 infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature 2022, PMID:35922517. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
SARS-CoV-2 infection (rs35508621). MyGeneLog™. https://www.mygenelog.com/variants/rs35508621