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Who was studied 46,802 European ancestry cases, 347,481 European ancestry controls; replicated in 23,948 European and unknown ancestry cases, 118,538 European and unknown ancestry controls.
The effect
Each copy of the T allele carried 1.07 times the odds of Asthma (95% confidence interval 1.05-1.09); p = 7 × 10−11.
How common The T allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 0.7 kb from HLA-DPA1.
What each result means
C/CNo copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Asthma. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
The European respiratory journal · 2019 · PMID 31619474
Questions about rs35449774
What is rs35449774?
rs35449774 is a single position in the genome, in or near the HLA-DPA1 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35449774 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs35449774 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35449774 come from?
GWAS Catalog, The European respiratory journal 2019, PMID:31619474. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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