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Who was studied 53,711 European ancestry female cases, 380,441 European ancestry female controls.
The effect
Each copy of the A allele shifted the measure 0.0471 higher (95% confidence interval 0.032-0.062); p = 4 × 10−10.
Where it sits Chromosome 22, band 22q13.2 — in an intron of RANGAP1.
What each result means
A/ATwo copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40050615 · open access
Questions about rs35445172
What is rs35445172?
rs35445172 is a single position in the genome, in or near the RANGAP1 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35445172 linked to?
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
Does having rs35445172 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35445172 come from?
GWAS Catalog, Nature communications 2025, PMID:40050615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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