Sensitive

Coronary artery disease (MTAG)

RYK · rs35432681

Where this position leads

Condition: Coronary Artery Disease

rs35432681 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs35432681 rs35432681 RYK

What the study found

Who was studied 310,368 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 5.48 z-score higher; p = 4 × 10−8.

How common The C allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 3, band 3q22.2 — in an intron of RYK.

What each result means

C/C Two copies of the version the research linked to Coronary artery disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Coronary artery disease (MTAG). That is a smaller link than two copies.
T/T No copy of the version the research linked to Coronary artery disease (MTAG). This is the starting point the study compared everyone against.
Source

Questions about rs35432681

What is rs35432681?

rs35432681 is a single position in the genome, in or near the RYK gene. Published research associates it with coronary artery disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35432681 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs35432681 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35432681 come from?

GWAS Catalog, NPJ genomic medicine 2025, PMID:41022758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Coronary artery disease (MTAG) (rs35432681). MyGeneLog™. https://www.mygenelog.com/variants/rs35432681

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