Serum 25-Hydroxyvitamin D levels (conditioned on BMI)
PADI1 · rs35408430
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 417,580 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.022 lower (95% confidence interval -0.026--0.018); p = 2 × 10−25.
How common The C allele had a frequency of about 66% in the people studied.
Where it sits Chromosome 1, band 1p36.13 — in an intron of PADI1.
What each result means
C/CTwo copies of the version the research linked to Serum 25-Hydroxyvitamin D levels (conditioned on BMI). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Serum 25-Hydroxyvitamin D levels (conditioned on BMI). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Serum 25-Hydroxyvitamin D levels (conditioned on BMI). This is the starting point the study compared everyone against.
Nature communications · 2020 · PMID 32242144 · open access
Questions about rs35408430
What is rs35408430?
rs35408430 is a single position in the genome, in or near the PADI1 gene. Published research associates it with serum 25-hydroxyvitamin d levels (conditioned on bmi). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35408430 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35408430 come from?
GWAS Catalog, Nature communications 2020, PMID:32242144. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Serum 25-Hydroxyvitamin D levels (conditioned on BMI) (rs35408430). MyGeneLog™. https://www.mygenelog.com/variants/rs35408430