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Body mass index

FOXO3 · rs35396874

Where this position leads

Conditions: Childhood Body Mass Index, Obesity and Body Weight

rs35396874 Condition: Childhood Body Mass Index Childhood Body Mass Index Condition Condition: Obesity and Body Weight Obesity and Body Weight Condition rs35396874 rs35396874 FOXO3

What the study found

Who was studied 163,835 East Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0219 higher (95% confidence interval 0.014-0.029); p = 7 × 10−9.

How common The T allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 6, band 6q21 — in an intron of FOXO3.

What each result means

C/C No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs35396874

What is rs35396874?

rs35396874 is a single position in the genome, in or near the FOXO3 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35396874 linked to?

On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs35396874 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35396874 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs35396874). MyGeneLog™. https://www.mygenelog.com/variants/rs35396874

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