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Skin pigmentation

SLC45A2 · rs35395

What the study found

Who was studied 1,047 Hispanic/Latin American individuals, 684 Cape Verdian individuals, 373 African American individuals; replicated in East African ancestry individuals (See Crawford et. al, 2017).

The effect Each copy of the T allele shifted the measure 0.321 lower (95% confidence interval 0.26-0.38); p = 2 × 10−24.

Where it sits Chromosome 5, band 5p13.2 — in an intron of SLC45A2.

What each result means

C/C No copy of the version the research linked to Skin pigmentation. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Skin pigmentation. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Skin pigmentation. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs35395

What is rs35395?

rs35395 is a single position in the genome, in or near the SLC45A2 gene. Published research associates it with skin pigmentation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35395 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35395 come from?

GWAS Catalog, BMC genetics 2019, PMID:31315583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Skin pigmentation (rs35395). MyGeneLog™. https://www.mygenelog.com/variants/rs35395

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