Gene Knowledge Graph
UTC
Standard

Tanning

MATP · rs35391

Where this position leads

Condition: Eye Color and Pigmentation

rs35391 Condition: Eye Color and Pigmentation Eye Color and Pigmentation Condition rs35391 rs35391 MATP

What the study found

Who was studied 2,287 European ancestry female individuals; replicated in 870 European ancestry female individuals.

The effect Each copy of the T allele shifted the measure 0.44 tanning ability score lower (95% confidence interval 0.30-0.58); p = 3 × 10−10.

Where it sits Chromosome 5, band 5p13.2 — in an intron of SLC45A2.

What each result means

C/C No copy of the version the research linked to Tanning. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Tanning. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Tanning. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association study of tanning phenotype in a population of European ancestry
Nan H, Kraft P, Qureshi AA, Guo Q, Chen C, Hankinson SE, Hu FB, Thomas G, Hoover RN, Chanock S, Hunter DJ, Han J
The Journal of investigative dermatology · 2009 · PMID 19340012

Questions about rs35391

What is rs35391?

rs35391 is a single position in the genome, in or near the MATP gene. Published research associates it with tanning. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35391 linked to?

On MyGeneLog this position is linked to Eye Color and Pigmentation. The research behind each link, and its sources, are set out on that condition page.

Does having rs35391 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35391 come from?

GWAS Catalog, J Invest Dermatol 2009, PMID:19340012. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Tanning (rs35391). MyGeneLog™. https://www.mygenelog.com/variants/rs35391

← See all variants