Sensitive

Colorectal cancer

CTNNB1 · rs35360328

Where this position leads

What the study found

Who was studied 18,299 European ancestry cases, 19,656 European ancestry controls; replicated in 4,725 East Asian ancestry cases, 9,969 East Asian ancestry controls.

The effect The catalogue records no effect size; p = 2 × 10⁻⁸.

Where it sits Chromosome 3, band 3p22.1 — inside LOC105377043.

What each result means

A/A Two copies of the version the research linked to Colorectal cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/T One copy of the version the research linked to Colorectal cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Colorectal cancer. This is the starting point the study compared everyone against.

Source

Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Schumacher FR, Schmit SL, Jiao S, Edlund CK, Wang H, Zhang B, Hsu L, Huang SC, Fischer CP, Harju JF, Idos GE, Lejbkowicz F

and 93 more — show all

Manion FJ, McDonnell K, McNeil CE, Melas M, Rennert HS, Shi W, Thomas DC, Van Den Berg DJ, Hutter CM, Aragaki AK, Butterbach K, Caan BJ, Carlson CS, Chanock SJ, Curtis KR, Fuchs CS, Gala M, Giovannucci EL, Gogarten SM, Hayes RB, Henderson B, Hunter DJ, Jackson RD, Kolonel LN, Kooperberg C, Küry S, LaCroix A, Laurie CC, Laurie CA, Lemire M, Levine D, Ma J, Makar KW, Qu C, Taverna D, Ulrich CM, Wu K, Kono S, West DW, Berndt SI, Bezieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Coetzee GA, Conti DV, Duggan D, Figueiredo JC, Fortini BK, Gallinger SJ, Gauderman WJ, Giles G, Green R, Haile R, Harrison TA, Hoffmeister M, Hopper JL, Hudson TJ, Hudson TJ, Jacobs E, Jacobs E, Iwasaki M, Jee SH, Jenkins M, Jia WH, Joshi A, Li L, Lindor NM, Matsuo K, Moreno V, Mukherjee B, Newcomb PA, Potter JD, Potter JD, Raskin L, Rennert G, Rosse S, Severi G, Schoen RE, Seminara D, Shu XO, Slattery ML, Tsugane S, White E, Xiang YB, Zanke BW, Zheng W, Zheng W, Le Marchand L, Casey G, Gruber SB, Peters U

Nature communications · 2015 · PMID 26151821

Questions about rs35360328

What is rs35360328?

rs35360328 is a single position in the genome, in or near the CTNNB1 gene. Published research associates it with colorectal cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35360328 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs35360328 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35360328 come from?

GWAS Catalog, Nat Commun 2015, PMID:26151821. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Colorectal cancer (rs35360328). MyGeneLog™. https://www.mygenelog.com/variants/rs35360328

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