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Inguinal hernia

SRPX · rs35318931

Where this position leads

Condition: Inguinal Hernia

rs35318931 Condition: Inguinal Hernia Inguinal Hernia Condition rs35318931 rs35318931 SRPX

What the study found

Who was studied 461 African American or African ancestry cases, 10,141 African American or African ancestry controls, 33,379 European ancestry cases, 436,717 European ancestry controls, 433 East Asian ancestry cases, 8,318 East Asian ancestry controls, 725 Hispanic or Latin American cases, 6,883 Hispanic or Latin American controls, 435 South Asian ancestry cases, 8,482 South Asian ancestry controls, 341 mixed ancestry cases, 6,805 mixed ancestry controls; replicated in 559 African American or African ancestry cases, 23,053 African American or African ancestry controls, 30,322 European ancestry cases, 580,593 European ancestry controls, 174 East Asian ancestry cases, 12,619 East Asian ancestry controls, 2,341 Hispanic or Latin American cases, 75,507 Hispanic or Latin American controls, 95 South Asian ancestry cases, 3,155 South Asian ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 8 × 10−29.

Where it sits Chromosome X, band Xp11.4 — a missense change in SRPX.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Inguinal hernia compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Inguinal hernia.
G/G Published research associates this genotype with typical/baseline likelihood of Inguinal hernia — no copies of the reported risk allele.
Source
Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis
Choquet H, Li W, Yin J, Bradley R, Hoffmann TJ, Nandakumar P, Mostaedi R, Tian C, Ahituv N, Jorgenson E
23 and Me Research Team
Human molecular genetics · 2022 · PMID 35022708 · open access

Questions about rs35318931

What is rs35318931?

rs35318931 is a single position in the genome, in or near the SRPX gene. Published research associates it with inguinal hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35318931 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs35318931 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35318931 come from?

GWAS Catalog, Human molecular genetics 2022, PMID:35022708. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Inguinal hernia (rs35318931). MyGeneLog™. https://www.mygenelog.com/variants/rs35318931

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