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Serum alkaline phosphatase levels

CLEC10A · rs35318160

What the study found

Who was studied 342,535 European ancestry individuals, 6,019 African ancestry individuals, 7,337 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0718 lower (95% confidence interval 0.057-0.087); p = 2 × 10−20.

Where it sits Chromosome 17, band 17p13.1 — a missense change in CLEC10A.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum alkaline phosphatase levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum alkaline phosphatase levels.
G/G Published research associates this genotype with typical/baseline likelihood of Serum alkaline phosphatase levels — no copies of the reported risk allele.
Source

Questions about rs35318160

What is rs35318160?

rs35318160 is a single position in the genome, in or near the CLEC10A gene. Published research associates it with serum alkaline phosphatase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35318160 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35318160 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Serum alkaline phosphatase levels (rs35318160). MyGeneLog™. https://www.mygenelog.com/variants/rs35318160

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