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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,004,040 European ancestry individuals; replicated in 417,288 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.00365 lower (95% confidence interval 0.0031-0.0042); p = 4 × 10−34.
How common The A allele had a frequency of about 21% in the people studied.
Where it sits Chromosome 17, band 17q12 — in an intron of FBXL20.
What each result means
A/ATwo copies of the version the research linked to Estimated glomerular filtration rate (creatinine). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Estimated glomerular filtration rate (creatinine). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Estimated glomerular filtration rate (creatinine). This is the starting point the study compared everyone against.
Nature communications · 2021 · PMID 34272381 · open access
Questions about rs35289683
What is rs35289683?
rs35289683 is a single position in the genome, in or near the FBXL20 gene. Published research associates it with estimated glomerular filtration rate (creatinine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35289683 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35289683 come from?
GWAS Catalog, Nature communications 2021, PMID:34272381. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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