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Who was studied at least 71,880 European ancestry cases, at least 383,378 European ancestry controls (MTAG boosted by 185,000 coronary artery disease samples).
The effect
Each copy of the A allele shifted the measure 0.105 higher (95% confidence interval 0.088-0.121); p = 1 × 10−36.
Where it sits Chromosome 19, band 19q13.32 — in an intron of RELB.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer's disease (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer's disease (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs35255921
What is rs35255921?
rs35255921 is a single position in the genome, in or near the RELB gene. Published research associates it with alzheimer's disease (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35255921 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs35255921 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35255921 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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