Standard
Antineutrophil cytoplasmic antibody-associated vasculitis
HLA-DQA1 · rs35242582
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Antineutrophil cytoplasmic antibody-associated vasculitis compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Antineutrophil cytoplasmic antibody-associated vasculitis.
G/G
Published research associates this genotype with typical/baseline likelihood of Antineutrophil cytoplasmic antibody-associated vasculitis — no copies of the reported risk allele.
Source
Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
Merkel PA,
Xie G,
Monach PA,
Ji X,
Ciavatta DJ,
Byun J,
Pinder BD,
Zhao A,
Zhang J,
Tadesse Y,
Qian D,
Weirauch M
and 32 more — show all
Nair R,
Tsoi A,
Pagnoux C,
Carette S,
Chung S,
Cuthbertson D,
Davis JC Jr,
Dellaripa PF,
Forbess L,
Gewurz-Singer O,
Hoffman GS,
Khalidi N,
Koening C,
Langford CA,
Mahr AD,
McAlear C,
Moreland L,
Seo EP,
Specks U,
Spiera RF,
Sreih A,
St Clair EW,
Stone JH,
Ytterberg SR,
Elder JT,
Qu J,
Ochi T,
Hirano N,
Edberg JC,
Falk RJ,
Amos CI,
Siminovitch KA
Arthritis & rheumatology (Hoboken, N.J.) · 2017 · PMID 28029757 · open access
Questions about rs35242582
What is rs35242582?
rs35242582 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with antineutrophil cytoplasmic antibody-associated vasculitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs35242582 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35242582 come from?
GWAS Catalog, Arthritis Rheumatol 2016, PMID:28029757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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