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Its strongest genetic-study result is p = 10−22, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 1,015 European ancestry granulomatosis with polyangiitis cases, 206 European ancestry microscopic polyangiitis cases, 3,258 European ancestry controls.; replicated in 541 European ancestry granulomatosis with polyangiitis cases, 30 European ancestry microscopic polyangiitis cases, 1,465 European ancestry controls..
The effect
Each copy of the A allele carried 1.60 times the odds of Antineutrophil cytoplasmic antibody-associated vasculitis (95% confidence interval 1.46-1.76); p = 6 × 10−23.
How common The A allele had a frequency of about 74% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — inside HLA-DQA1.
What each result means
A/ATwo copies of the version the research linked to Antineutrophil cytoplasmic antibody-associated vasculitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Antineutrophil cytoplasmic antibody-associated vasculitis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Antineutrophil cytoplasmic antibody-associated vasculitis. This is the starting point the study compared everyone against.
rs35242582 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with antineutrophil cytoplasmic antibody-associated vasculitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35242582 linked to?
On MyGeneLog this position is linked to ANCA-Associated Vasculitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs35242582 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35242582 come from?
GWAS Catalog, Arthritis Rheumatol 2016, PMID:28029757. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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