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Childhood ear infection

AUTS2 · rs35213789

Where this position leads

Condition: Tonsillectomy (Throat Infection Susceptibility)

What the study found

Who was studied 46,936 European ancestry cases, 74,874 European ancestry controls.

The effect Each copy of the C allele carried 1.06 times the odds of Childhood ear infection (95% confidence interval 1.05-1.07); p = 4 × 10⁻⁹.

How common The C allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 7, band 7q11.22 — in an intron of AUTS2.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Childhood ear infection compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Childhood ear infection.

T/T Published research associates this genotype with typical/baseline likelihood of Childhood ear infection — no copies of the reported risk allele.

Source

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA

Nature communications · 2017 · PMID 28928442 · open access

Questions about rs35213789

What is rs35213789?

rs35213789 is a single position in the genome, in or near the AUTS2 gene. Published research associates it with childhood ear infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35213789 linked to?

On MyGeneLog this position is linked to Tonsillectomy (Throat Infection Susceptibility). The research behind each link, and its sources, are set out on that condition page.

Does having rs35213789 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35213789 come from?

GWAS Catalog, Nat Commun 2017, PMID:28928442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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