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Phospholipids in small HDL

near CHCHD7 · rs35205529

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs35205529 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs35205529 rs35205529 near CHCHD7

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the T allele shifted the measure 0.02 mmol/L higher (95% confidence interval 0.02-0.02); p = 1 × 10−10.

Where it sits Chromosome 8, band 8q12.1 — between genes, 30.7 kb from CHCHD7.

What each result means

C/C No copy of the version the research linked to Phospholipids in small HDL. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Phospholipids in small HDL. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Phospholipids in small HDL. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs35205529

What is rs35205529?

rs35205529 is a single position in the genome, in or near the near CHCHD7 gene. Published research associates it with phospholipids in small hdl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35205529 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs35205529 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35205529 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Phospholipids in small HDL (rs35205529). MyGeneLog™. https://www.mygenelog.com/variants/rs35205529

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