A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cirrhosis compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cirrhosis.
G/GPublished research associates this genotype with typical/baseline likelihood of Primary biliary cirrhosis — no copies of the reported risk allele.
Nature genetics · 2012 · PMID 22961000 · open access
Questions about rs35188261
What is rs35188261?
rs35188261 is a single position in the genome, in or near the IRF5 gene. Published research associates it with primary biliary cirrhosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35188261 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs35188261 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35188261 come from?
GWAS Catalog, Nat Genet 2012, PMID:22961000. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.