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Apolipoprotein A1 levels

SULF2 · rs35164685

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 311,601 European ancestry individuals, 5,550 African ancestry individuals, 6,682 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0202 higher (95% confidence interval 0.014-0.026); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 20, band 20q13.12 — in an intron of SULF2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Apolipoprotein A1 levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Apolipoprotein A1 levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Apolipoprotein A1 levels compared to the general population.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs35164685

What is rs35164685?

rs35164685 is a single position in the genome, in or near the SULF2 gene. Published research associates it with apolipoprotein a1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35164685 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35164685 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Apolipoprotein A1 levels (rs35164685). MyGeneLog™. https://www.mygenelog.com/variants/rs35164685

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