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Angioedema in response to angiotensin-converting enzyme inhibitor

near BDKRB2 · rs35136400

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,060 European ancestry cases, 77,799 European ancestry controls.

The effect Each copy of the A allele carried 1.50 times the odds of Angioedema in response to angiotensin-converting enzyme inhibitor (95% confidence interval 1.39-1.61); p = 1 × 10−12.

Where it sits Chromosome 14, band 14q32.2 — between genes, 51.4 kb from BDKRB2.

What each result means

A/A Two copies of the version the research linked to Angioedema in response to angiotensin-converting enzyme inhibitor. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Angioedema in response to angiotensin-converting enzyme inhibitor. That is a smaller link than two copies.
G/G No copy of the version the research linked to Angioedema in response to angiotensin-converting enzyme inhibitor. This is the starting point the study compared everyone against.
Source
Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus
Mathey CM, Maj C, Eriksson N, Krebs K, Westmeier J, David FS, Koromina M, Scheer AB, Szabo N, Wedi B, Wieczorek D, Amann PM
and 39 more — show all
Löffler H, Koch L, Schöffl C, Dickel H, Ganjuur N, Hornung T, Buhl T, Greve J, Wurpts G, Aygören-Pürsün E, Steffens M, Herms S, Heilmann-Heimbach S, Hoffmann P, Schmidt B, Mavarani L, Andresen T, Sørensen SB, Andersen V, Vogel U, Landén M, Bulik CM, Bygum A, Magnusson PKE, von Buchwald C, Hallberg P, Rye Ostrowski S, Sørensen E, Pedersen OB, Ullum H, Erikstrup C, Bundgaard H, Milani L, Rasmussen ER, Wadelius M, Ghouse J, Sachs B, Nöthen MM, Forstner AJ
Estonian Biobank Research Team · DBDS Genomic Consortium
The Journal of allergy and clinical immunology · 2024 · PMID 38300190

Questions about rs35136400

What is rs35136400?

rs35136400 is a single position in the genome, in or near the near BDKRB2 gene. Published research associates it with angioedema in response to angiotensin-converting enzyme inhibitor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs35136400 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35136400 come from?

GWAS Catalog, The Journal of allergy and clinical immunology 2024, PMID:38300190. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Angioedema in response to angiotensin-converting enzyme inhibitor (rs35136400). MyGeneLog™. https://www.mygenelog.com/variants/rs35136400

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