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Male-pattern baldness

RUNX1 · rs35068491

Where this position leads

Condition: Androgenetic Alopecia (Male Pattern Baldness)

rs35068491 Condition: Androgenetic Alopecia (Male Pattern Baldness) Androgenetic Alopecia (Male Pattern… Condition rs35068491 rs35068491 RUNX1

What the study found

Who was studied 205,327 European ancestry males.

The effect Each copy of the C allele shifted the measure 0.0403 lower (95% confidence interval 0.033-0.048); p = 5 × 10−26.

How common The C allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 21, band 21q22.12 — in an intron of RUNX1-AS1.

What each result means

C/C Two copies of the version the research linked to Male-pattern baldness. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Male-pattern baldness. That is a smaller link than two copies.
T/T No copy of the version the research linked to Male-pattern baldness. This is the starting point the study compared everyone against.
Source

Questions about rs35068491

What is rs35068491?

rs35068491 is a single position in the genome, in or near the RUNX1 gene. Published research associates it with male-pattern baldness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35068491 linked to?

On MyGeneLog this position is linked to Androgenetic Alopecia (Male Pattern Baldness). The research behind each link, and its sources, are set out on that condition page.

Does having rs35068491 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35068491 come from?

GWAS Catalog, Nat Commun 2018, PMID:30573740. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Male-pattern baldness (rs35068491). MyGeneLog™. https://www.mygenelog.com/variants/rs35068491

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