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Who was studied 437,438 European ancestry individuals; replicated in 315,572 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.00212 lower (95% confidence interval 0.0016-0.0026); p = 6 × 10−20.
How common The G allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 10, band 10q23.33 — between genes, 9.2 kb from RPL7AP52.
What each result means
A/ANo copy of the version the research linked to Liver enzyme levels (alkaline phosphatase). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Liver enzyme levels (alkaline phosphatase). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Liver enzyme levels (alkaline phosphatase). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33972514 · open access
Questions about rs35013847
What is rs35013847?
rs35013847 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with liver enzyme levels (alkaline phosphatase). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs35013847 affect how medicines work?
CYP2C19 carries pharmacogenomic findings for Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs35013847 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35013847 come from?
GWAS Catalog, Nat Commun 2021, PMID:33972514. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
6 4652115222224Reads by AI crawlersClaude5ChatGPT2Google · Gemini1Perplexity1Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others24Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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