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Who was studied 342,087 European ancestry individuals, 6,011 African ancestry individuals, 7,328 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.142 higher (95% confidence interval 0.11-0.17); p = 4 × 10−17.
Where it sits Chromosome 11, band 11q13.1 — a stop-gain change in SLC22A11.
What ClinVar records
ClassificationLikely benign for SLC22A11-related disorder; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2025-01-01.
ClinVar record 3038511NM_018484.4(SLC22A11):c.142C>T (p.Arg48Ter)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Urate levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Urate levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Urate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs35008345
What is rs35008345?
rs35008345 is a single position in the genome, in or near the SLC22A11 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs35008345 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs35008345 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs35008345 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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