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Umbilical hernia (PheCode 550.4)

EPHB2 · rs35001652

Where this position leads

Condition: Umbilical Hernia

rs35001652 Condition: Umbilical Hernia Umbilical Hernia Condition rs35001652 rs35001652 EPHB2

What the study found

Who was studied 3,037 African American or Afro-Caribbean cases, 116,998 African American or Afro-Caribbean controls, 15,292 European ancestry cases, 428,443 European ancestry controls, 1,859 Hispanic or Latin American cases, 57,236 Hispanic or Latin American controls.

The effect Each copy of the G allele shifted the measure 0.0913 lower (95% confidence interval 0.07-0.112); p = 2 × 10−14.

How common The G allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 1, band 1p36.12 — in an intron of EPHB2.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Umbilical hernia (PheCode 550.4) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Umbilical hernia (PheCode 550.4).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Umbilical hernia (PheCode 550.4) compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs35001652

What is rs35001652?

rs35001652 is a single position in the genome, in or near the EPHB2 gene. Published research associates it with umbilical hernia (phecode 550.4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs35001652 linked to?

On MyGeneLog this position is linked to Umbilical Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs35001652 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs35001652 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Umbilical hernia (PheCode 550.4) (rs35001652). MyGeneLog™. https://www.mygenelog.com/variants/rs35001652

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