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Who was studied 2,177 Erasmus Rucphen Family (founder/genetic isolate) individuals, 23,332 European ancestry individuals; replicated in 391 Carlantino (founder/genetic isolate) individuals, 981 Friuli Venezia Giulia (founder/genetic isolate) individuals, 30,760 European ancestry individuals, 2,048 African American individuals.
The effect
Each copy of the A allele shifted the measure 0.81 lower (95% confidence interval 0.62-1); p = 2 × 10−16.
How common The A allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 14, band 14q24.2 — in an intron of SIPA1L1.
What each result means
A/ATwo copies of the version the research linked to QRS duration. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to QRS duration. That is a smaller link than two copies.
G/GNo copy of the version the research linked to QRS duration. This is the starting point the study compared everyone against.
European journal of human genetics : EJHG · 2019 · PMID 30679814 · open access
Questions about rs34991781
What is rs34991781?
rs34991781 is a single position in the genome, in or near the SIPA1L1 gene. Published research associates it with qrs duration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34991781 linked to?
On MyGeneLog this position is linked to Cardiac Conduction Intervals (PR Interval and QRS Duration). The research behind each link, and its sources, are set out on that condition page.
Does having rs34991781 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34991781 come from?
GWAS Catalog, European journal of human genetics : EJHG 2019, PMID:30679814. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 6123Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others3Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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