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Who was studied at least 170,756 European ancestry cases, at least 329,443 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0294 lower (95% confidence interval 0.021-0.038); p = 1 × 10−11.
How common The A allele had a frequency of about 63% in the people studied.
Where it sits Chromosome 5, band 5q21.2 — in an intron of NIHCOLE.
What each result means
A/ATwo copies of the version the research linked to Major depressive disorder (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Major depressive disorder (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Major depressive disorder (MTAG). This is the starting point the study compared everyone against.
Translational psychiatry · 2021 · PMID 33479212 · open access
Questions about rs349588
What is rs349588?
rs349588 is a single position in the genome, in or near the NIHCOLE gene. Published research associates it with major depressive disorder (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs349588 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs349588 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs349588 come from?
GWAS Catalog, Translational psychiatry 2021, PMID:33479212. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Major depressive disorder (MTAG) (rs349588). MyGeneLog™. https://www.mygenelog.com/variants/rs349588