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Its strongest genetic-study result is p = 10−13, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 43,861 Japanese ancestry women; replicated in 32,545 European ancestry women.
The effect
Each copy of the T allele shifted the measure 0.2 year higher (95% confidence interval 0.14-0.26); p = 9 × 10−14.
How common The T allele had a frequency of about 49% in the people studied.
Where it sits Chromosome 5, band 5q35.2 — in an intron of ZNF346.
What each result means
G/GNo copy of the version the research linked to Menopause (age at onset). This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Menopause (age at onset). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Menopause (age at onset). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 29773799 · open access
Questions about rs34933909
What is rs34933909?
rs34933909 is a single position in the genome, in or near the UIMC1 gene. Published research associates it with menopause (age at onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34933909 linked to?
On MyGeneLog this position is linked to Age at Menopause. The research behind each link, and its sources, are set out on that condition page.
Does having rs34933909 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34933909 come from?
GWAS Catalog, Nat Commun 2018, PMID:29773799. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Menopause (age at onset) (rs34933909). MyGeneLog™. https://www.mygenelog.com/variants/rs34933909