Sensitive

Coronary artery disease

GUCY1A3 · rs34914832

Where this position leads

Condition: Coronary Artery Disease

rs34914832 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs34914832 rs34914832 GUCY1A3

What the study found

Who was studied 15,302 Japanese ancestry cases, 76,014 European and East Asian ancestry cases, 36,140 Japanese ancestry controls, 264,785 European and East Asian ancestry controls.

The effect Each copy of the G allele carried 1.07 times the odds of Coronary artery disease (95% confidence interval 1.05-1.08); p = 3 × 10−11.

How common The G allele had a frequency of about 79% in the people studied.

Where it sits Chromosome 4, band 4q32.1 — in an intron of GUCY1A1.

What each result means

A/A No copy of the version the research linked to Coronary artery disease. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Coronary artery disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs34914832

What is rs34914832?

rs34914832 is a single position in the genome, in or near the GUCY1A3 gene. Published research associates it with coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34914832 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs34914832 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34914832 come from?

GWAS Catalog, Circulation. Genomic and precision medicine 2020, PMID:32469254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Coronary artery disease (rs34914832). MyGeneLog™. https://www.mygenelog.com/variants/rs34914832

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