0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 164,933 European ancestry major depressive disorder cases, 20,352 European ancestry bipolar disorder cases, 439,741 European ancestry controls.
The effect
Each copy of the T allele carried 1.03 times the odds of Bipolar disorder or major depressive disorder (95% confidence interval 1.02-1.04); p = 2 × 10−8.
Where it sits Chromosome 7, band 7q21.11 — in an intron of PCLO.
What each result means
C/CNo copy of the version the research linked to Bipolar disorder or major depressive disorder. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Bipolar disorder or major depressive disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Bipolar disorder or major depressive disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs34866621 is a single position in the genome, in or near the PCLO gene. Published research associates it with bipolar disorder or major depressive disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34866621 linked to?
On MyGeneLog this position is linked to Major Depressive Disorder. The research behind each link, and its sources, are set out on that condition page.
Does having rs34866621 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34866621 come from?
GWAS Catalog, Biological psychiatry 2020, PMID:31926635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Bipolar disorder or major depressive disorder (rs34866621). MyGeneLog™. https://www.mygenelog.com/variants/rs34866621