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Alcohol consumption (drinks per week) (MTAG)

CLN3 · rs34836

Where this position leads

Condition: Alcohol Consumption

rs34836 Condition: Alcohol Consumption Alcohol Consumption Condition rs34836 rs34836 CLN3

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Alcohol consumption (drinks per week) (MTAG) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alcohol consumption (drinks per week) (MTAG).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alcohol consumption (drinks per week) (MTAG) compared to the general population.
Source
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY
and 15 more — show all
Atkinson SR, Thursz MR, Nyegaard M, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J
Nature neuroscience · 2020 · PMID 32451486 · open access

Questions about rs34836

What is rs34836?

rs34836 is a single position in the genome, in or near the CLN3 gene. Published research associates it with alcohol consumption (drinks per week) (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34836 linked to?

On MyGeneLog this position is linked to Alcohol Consumption. The research behind each link, and its sources, are set out on that condition page.

Does having rs34836 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34836 come from?

GWAS Catalog, Nature neuroscience 2020, PMID:32451486. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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