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Apolipoprotein A1 levels

CNOT1 · rs34830321

What the study found

Who was studied 393,193 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.054 higher (95% confidence interval 0.037-0.071); p = 3 × 10−10.

How common The C allele had a frequency of about 99% in the people studied.

Where it sits Chromosome 16, band 16q21 — a missense change in CNOT1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Apolipoprotein A1 levels compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Apolipoprotein A1 levels.
T/T Published research associates this genotype with typical/baseline likelihood of Apolipoprotein A1 levels — no copies of the reported risk allele.
Source

Questions about rs34830321

What is rs34830321?

rs34830321 is a single position in the genome, in or near the CNOT1 gene. Published research associates it with apolipoprotein a1 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs34830321 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34830321 come from?

GWAS Catalog, PLoS medicine 2020, PMID:32203549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Apolipoprotein A1 levels (rs34830321). MyGeneLog™. https://www.mygenelog.com/variants/rs34830321

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