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Neutrophil-to-lymphocyte ratio

near RPN1 · rs34762068

What the study found

Who was studied 234,502 European ancestry individuals; replicated in 100,442 European ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 2 × 10−21.

How common The G allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 3, band 3q21.3 — between genes, 13 kb from RPN1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Neutrophil-to-lymphocyte ratio — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neutrophil-to-lymphocyte ratio.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neutrophil-to-lymphocyte ratio compared to the general population.
Source

Questions about rs34762068

What is rs34762068?

rs34762068 is a single position in the genome, in or near the near RPN1 gene. Published research associates it with neutrophil-to-lymphocyte ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs34762068 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34762068 come from?

GWAS Catalog, American journal of human genetics 2021, PMID:34469753. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Neutrophil-to-lymphocyte ratio (rs34762068). MyGeneLog™. https://www.mygenelog.com/variants/rs34762068

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