SHARPIN · rs34674752
Where this position leads
Condition: Alzheimer's Disease
What the study found
Who was studied 56,184 European ancestry cases, 90,919 European ancestry controls.
The effect Each copy of the A allele carried 1.13 times the odds of Alzheimer's disease (95% confidence interval 1.08-1.18); p = 8 × 10−9.
How common The A allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 8, band 8q24.3 — a missense change in SHARPIN.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2016-03-29.
ClinVar record 403432 NM_030974.4(SHARPIN):c.880C>T (p.Pro294Ser)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs34674752 is a single position in the genome, in or near the SHARPIN gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2026, PMID:42237039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Alzheimer's disease (rs34674752). MyGeneLog™. https://www.mygenelog.com/variants/rs34674752