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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 2,223 European ancestry individuals; replicated in 1,667 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 1.22 lower (95% confidence interval 0.8-1.65); p = 2 × 10−8.
How common The A allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 6, band 6p22.3 — in an intron of ATXN1.
What each result means
A/ATwo copies of the version the research linked to Gut microbiota (bacterial taxa, hurdle binary method). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Gut microbiota (bacterial taxa, hurdle binary method). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Gut microbiota (bacterial taxa, hurdle binary method). This is the starting point the study compared everyone against.
Nature microbiology · 2020 · PMID 32572223 · open access
Questions about rs34656657
What is rs34656657?
rs34656657 is a single position in the genome, in or near the ATXN1 gene. Published research associates it with gut microbiota (bacterial taxa, hurdle binary method). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34656657 linked to?
On MyGeneLog this position is linked to Gut Microbiota. The research behind each link, and its sources, are set out on that condition page.
Does having rs34656657 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34656657 come from?
GWAS Catalog, Nature microbiology 2020, PMID:32572223. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Gut microbiota (bacterial taxa, hurdle binary method) (rs34656657). MyGeneLog™. https://www.mygenelog.com/variants/rs34656657