HSD17B2-AS1 · rs34638657
Where this position leads
Condition: Lung Cancer
What the study found
Who was studied 59,774 European ancestry cases, 1,416,415 European ancestry controls, 11,773 East Asian ancestry cases, 288,419 East Asian ancestry controls, 4,782 African ancestry cases, 122,496 African ancestry controls, 624 Hispanic/Latino American ancestry cases, 59,042 Hispanic/Latino American ancestry controls.
The effect Each copy of the A allele shifted the measure 0.056 lower (95% confidence interval 0.04-0.072); p = 7 × 10−12.
How common The A allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 16, band 16q23.3 — in an intron of HSD17B2-AS1.
rs34638657 is a single position in the genome, in or near the HSD17B2-AS1 gene. Published research associates it with lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2026, PMID:42364979. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung cancer (rs34638657). MyGeneLog™. https://www.mygenelog.com/variants/rs34638657