Who was studied 1,972 Chinese ancestry cases, 2,478 Chinese ancestry controls; replicated in 8,209 Chinese ancestry cases, 9,454 Chinese ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.883 higher (95% confidence interval 0.69-1.07); p = 4 × 10−20.
Where it sits Chromosome 12, band 12q12 — a missense change in LRRK2.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Parkinson's disease — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Parkinson's disease.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Parkinson's disease compared to the general population.
rs34594498 is a single position in the genome, in or near the LRRK2 gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34594498 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs34594498 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34594498 come from?
GWAS Catalog, NPJ Parkinson's disease 2023, PMID:36759515. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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