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CTSS protein levels

TARS2 · rs34542152

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.131 higher (95% confidence interval 0.11-0.15); p = 2 × 10−38.

How common The T allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 1, band 1q21.2 — in an intron of TARS2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of CTSS protein levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with CTSS protein levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of CTSS protein levels compared to the general population.
Source

Questions about rs34542152

What is rs34542152?

rs34542152 is a single position in the genome, in or near the TARS2 gene. Published research associates it with ctss protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs34542152 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34542152 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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CTSS protein levels (rs34542152). MyGeneLog™. https://www.mygenelog.com/variants/rs34542152

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