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Sensitive

Amyotrophic lateral sclerosis (sporadic)

SALM1 · rs34517613

Where this position leads

Condition: Amyotrophic Lateral Sclerosis

rs34517613 Condition: Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Condition rs34517613 rs34517613 SALM1

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Amyotrophic lateral sclerosis (sporadic) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Amyotrophic lateral sclerosis (sporadic).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Amyotrophic lateral sclerosis (sporadic) compared to the general population.
Source
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis
Fogh I, Ratti A, Gellera C, Lin K, Tiloca C, Moskvina V, Corrado L, Sorarù G, Cereda C, Corti S, Gentilini D, Calini D
and 53 more — show all
Castellotti B, Mazzini L, Querin G, Gagliardi S, Del Bo R, Conforti FL, Siciliano G, Inghilleri M, Saccà F, Bongioanni P, Penco S, Corbo M, Sorbi S, Filosto M, Ferlini A, Di Blasio AM, Signorini S, Shatunov A, Jones A, Shaw PJ, Morrison KE, Farmer AE, Van Damme P, Robberecht W, Chiò A, Traynor BJ, Sendtner M, Melki J, Meininger V, Hardiman O, Andersen PM, Leigh NP, Glass JD, Overste D, Diekstra FP, Veldink JH, van Es MA, Shaw CE, Weale ME, Lewis CM, Williams J, Brown RH, Landers JE, Ticozzi N, Ceroni M, Pegoraro E, Comi GP, D'Alfonso S, van den Berg LH, Taroni F, Al-Chalabi A, Powell J, Silani V
SLAGEN Consortium and Collaborators
Human molecular genetics · 2014 · PMID 24256812

Questions about rs34517613

What is rs34517613?

rs34517613 is a single position in the genome, in or near the SALM1 gene. Published research associates it with amyotrophic lateral sclerosis (sporadic). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34517613 linked to?

On MyGeneLog this position is linked to Amyotrophic Lateral Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs34517613 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34517613 come from?

GWAS Catalog, Hum Mol Genet 2013, PMID:24256812. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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