Sensitive

Amyotrophic lateral sclerosis (sporadic)

SALM1 · rs34517613

Where this position leads

Condition: Amyotrophic Lateral Sclerosis

rs34517613 Condition: Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis Condition rs34517613 rs34517613 SALM1

What the study found

Who was studied 6,100 European ancestry cases, 7,125 European ancestry controls; replicated in 2,074 European ancestry cases, 2,556 European ancestry controls.

The effect Each copy of the T allele carried 1.20 times the odds of Amyotrophic lateral sclerosis (sporadic) (95% confidence interval 1.12-1.29); p = 9 × 10−9.

Where it sits Chromosome 17, band 17q11.2 — in an intron of KRT18P55.

What each result means

C/C No copy of the version the research linked to Amyotrophic lateral sclerosis (sporadic). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Amyotrophic lateral sclerosis (sporadic). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Amyotrophic lateral sclerosis (sporadic). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs34517613

What is rs34517613?

rs34517613 is a single position in the genome, in or near the SALM1 gene. Published research associates it with amyotrophic lateral sclerosis (sporadic). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34517613 linked to?

On MyGeneLog this position is linked to Amyotrophic Lateral Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs34517613 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34517613 come from?

GWAS Catalog, Hum Mol Genet 2013, PMID:24256812. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Amyotrophic lateral sclerosis (sporadic) (rs34517613). MyGeneLog™. https://www.mygenelog.com/variants/rs34517613

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