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Psoriasis

FUBP1 · rs34517439

Where this position leads

Conditions: Psoriasis, Osteoarthritis

rs34517439 Condition: Psoriasis Psoriasis Condition Condition: Osteoarthritis Osteoarthritis Condition rs34517439 rs34517439 FUBP1

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−38, with 78 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

How common each version is

AC
Japanese ToMMo
C 100.0%
World gnomAD
A 7.2% · C 92.8%
World 1000 Genomes
A 2.8% · C 97.2%
World TOPMed
A 6.6% · C 93.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. No Korean figure for this position yet.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
C/C No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source

Questions about rs34517439

What is rs34517439?

rs34517439 is a single position in the genome, in or near the FUBP1 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34517439 linked to?

On MyGeneLog this position is linked to Psoriasis, Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs34517439 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34517439 come from?

GWAS Catalog, Nat Commun 2017, PMID:28537254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs34517439). MyGeneLog™. https://www.mygenelog.com/variants/rs34517439

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