Angioedema in response to angiotensin-converting enzyme inhibitor
near C14orf132 · rs34485356
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 462 European ancestry ACE inhibitor-associated angioedema cases, 53,391 European ancestry ACE inhibitor-exposed controls; replicated in 142 European ancestry ACE inhibitor-associated angioedema cases, 1,345 European ancestry ACE inhibitor-exposed controls.
The effect
Each copy of the T allele carried 1.62 times the odds of Angioedema in response to angiotensin-converting enzyme inhibitor (95% confidence interval 1.4-1.87); p = 1 × 10−10.
How common The T allele had a frequency of about 77% in the people studied.
Where it sits Chromosome 14, band 14q32.2 — between genes, 51 kb from C14orf132.
What each result means
C/CNo copy of the version the research linked to Angioedema in response to angiotensin-converting enzyme inhibitor. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Angioedema in response to angiotensin-converting enzyme inhibitor. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Angioedema in response to angiotensin-converting enzyme inhibitor. That is the strongest link of the three results. A link in a study is not a diagnosis.
Journal of the American College of Cardiology · 2021 · PMID 34384552
Questions about rs34485356
What is rs34485356?
rs34485356 is a single position in the genome, in or near the near C14orf132 gene. Published research associates it with angioedema in response to angiotensin-converting enzyme inhibitor. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs34485356 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34485356 come from?
GWAS Catalog, Journal of the American College of Cardiology 2021, PMID:34384552. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Angioedema in response to angiotensin-converting enzyme inhibitor (rs34485356). MyGeneLog™. https://www.mygenelog.com/variants/rs34485356