Sensitive

Critical COVID-19 or osteoarthritis (MTAG)

near XCR1 · rs34460587

Where this position leads

Condition: Osteoarthritis

rs34460587 Condition: Osteoarthritis Osteoarthritis Condition rs34460587 rs34460587 near XCR1

What the study found

Who was studied 314,870 European ancestry individuals with osteoarthritis data, 1,388,342 European ancestry individuals with critical COVID-19 data.

The effect Each copy of the T allele shifted the measure 0.023 higher (95% confidence interval 0.019-0.027); p = 5 × 10−31.

Where it sits Chromosome 3, band 3p21.31 — between genes, 15.1 kb from XCR1.

What each result means

C/C No copy of the version the research linked to Critical COVID-19 or osteoarthritis (MTAG). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Critical COVID-19 or osteoarthritis (MTAG). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Critical COVID-19 or osteoarthritis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs34460587

What is rs34460587?

rs34460587 is a single position in the genome, in or near the near XCR1 gene. Published research associates it with critical covid-19 or osteoarthritis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34460587 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs34460587 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34460587 come from?

GWAS Catalog, Frontiers in immunology 2023, PMID:37398645. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Critical COVID-19 or osteoarthritis (MTAG) (rs34460587). MyGeneLog™. https://www.mygenelog.com/variants/rs34460587

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