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Pulse pressure

CRK · rs34457140

What the study found

Who was studied 295,529 European ancestry individuals, 8,231 Latino individuals, 3,058 African American individuals, 2,029 African British individuals, 7,701 East Asian ancestry individuals, 2,735 South Asian ancestry individuals, 1,979 mixed and unknown ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.163 lower; p = 3 × 10−10.

Where it sits Chromosome 17, band 17p13.3 — in an intron of CRK.

What each result means

G/G No copy of the version the research linked to Pulse pressure. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Pulse pressure. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Pulse pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs34457140

What is rs34457140?

rs34457140 is a single position in the genome, in or near the CRK gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs34457140 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34457140 come from?

GWAS Catalog, Nature genetics 2017, PMID:27841878. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Pulse pressure (rs34457140). MyGeneLog™. https://www.mygenelog.com/variants/rs34457140

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