0 251223116Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others16Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 342,376 European ancestry individuals, 6,016 African ancestry individuals, 7,339 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.136 lower (95% confidence interval 0.1-0.17); p = 2 × 10−16.
Where it sits Chromosome 2, band 2q31.1 — a missense change in LRP2.
What ClinVar records
ClassificationBenign/Likely benign for Donnai-Barrow syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 12 submitters), last evaluated 2026-04-01.
ClinVar record 129492NM_004525.3(LRP2):c.11092G>A (p.Val3698Met)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Creatinine levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Creatinine levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Creatinine levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs34355135
What is rs34355135?
rs34355135 is a single position in the genome, in or near the LRP2 gene. Published research associates it with creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs34355135 linked to?
On MyGeneLog this position is linked to Kidney Function, Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs34355135 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs34355135 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 251223116Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others16Total25Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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