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Takes medication for high blood pressure?

INSR · rs34328549

Where this position leads

Condition: Blood Pressure

rs34328549 Condition: Blood Pressure Blood Pressure Condition rs34328549 rs34328549 INSR

What the study found

Who was studied 35,848 African American or Afro-Caribbean cases, 19,657 African American or Afro-Caribbean controls, 14,901 Hispanic or Latin American cases, 14,413 Hispanic or Latin American controls, 1,884 East Asian ancestry cases, 1,663 East Asian ancestry controls, 179,356 European ancestry cases, 136,312 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0813 higher (95% confidence interval 0.062-0.101); p = 2 × 10−18.

How common The G allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 19, band 19p13.2 — in an intron of INSR.

What each result means

A/A No copy of the version the research linked to Takes medication for high blood pressure?. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Takes medication for high blood pressure?. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Takes medication for high blood pressure?. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs34328549

What is rs34328549?

rs34328549 is a single position in the genome, in or near the INSR gene. Published research associates it with takes medication for high blood pressure?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34328549 linked to?

On MyGeneLog this position is linked to Blood Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs34328549 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34328549 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Takes medication for high blood pressure? (rs34328549). MyGeneLog™. https://www.mygenelog.com/variants/rs34328549

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