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Vitamin B12 levels

TCN1 · rs34324219

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,001 Indo-European ancestry adults; replicated in 1,713 Indo-European ancestry adults, 690 Indo-European ancestry children, 481 Dravidian ancestry adults, 534 Dravidian ancestry children.

The effect Each copy of the A allele shifted the measure 0.34 pmol/l lower; p = 4 × 10⁻⁸.

Where it sits Chromosome 11, band 11q12.1 — a missense change in TCN1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Vitamin B12 levels compared to the general population.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Vitamin B12 levels.

C/C Published research associates this genotype with typical/baseline likelihood of Vitamin B12 levels — no copies of the reported risk allele.

Source

GWAS identifies population-specific new regulatory variants in FUT6 associated with plasma B12 concentrations in Indians

Nongmaithem SS, Joglekar CV, Krishnaveni GV, Sahariah SA, Ahmad M, Ramachandran S, Gandhi M, Chopra H, Pandit A, Potdar RD, H D Fall C, Yajnik CS

and 1 more — show all

Chandak GR

Human molecular genetics · 2017 · PMID 28334792 · open access

Questions about rs34324219

What is rs34324219?

rs34324219 is a single position in the genome, in or near the TCN1 gene. Published research associates it with vitamin b12 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs34324219 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34324219 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28334792. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants