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Ovarian cancer

BRIP1 · rs34289250

Where this position leads

Condition: Ovarian Cancer

rs34289250 Condition: Ovarian Cancer Ovarian Cancer Condition rs34289250 rs34289250 BRIP1

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Ovarian cancer compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Ovarian cancer.
T/T Published research associates this genotype with typical/baseline likelihood of Ovarian cancer — no copies of the reported risk allele.
Source
Mutations in BRIP1 confer high risk of ovarian cancer
Rafnar T, Gudbjartsson DF, Sulem P, Jonasdottir A, Sigurdsson A, Jonasdottir A, Besenbacher S, Lundin P, Stacey SN, Gudmundsson J, Magnusson OT, le Roux L
and 33 more — show all
Orlygsdottir G, Helgadottir HT, Johannsdottir H, Gylfason A, Tryggvadottir L, Jonasson JG, de Juan A, Ortega E, Ramon-Cajal JM, García-Prats MD, Mayordomo C, Panadero A, Rivera F, Aben KK, van Altena AM, Massuger LF, Aavikko M, Kujala PM, Staff S, Aaltonen LA, Olafsdottir K, Bjornsson J, Kong A, Salvarsdottir A, Saemundsson H, Olafsson K, Benediktsdottir KR, Gulcher J, Masson G, Kiemeney LA, Mayordomo JI, Thorsteinsdottir U, Stefansson K
Nature genetics · 2011 · PMID 21964575

Questions about rs34289250

What is rs34289250?

rs34289250 is a single position in the genome, in or near the BRIP1 gene. Published research associates it with ovarian cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34289250 linked to?

On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs34289250 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34289250 come from?

GWAS Catalog, Nat Genet 2011, PMID:21964575. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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