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Ascending aorta minimum area

KALRN · rs34266187

What the study found

Who was studied 35,110 individuals.

The effect Each copy of the G allele shifted the measure 0.044 lower (95% confidence interval 0.03-0.058); p = 3 × 10−10.

How common The G allele had a frequency of about 63% in the people studied.

Where it sits Chromosome 3, band 3q21.2 — in an intron of KALRN.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Ascending aorta minimum area — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Ascending aorta minimum area.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Ascending aorta minimum area compared to the general population.
Source

Questions about rs34266187

What is rs34266187?

rs34266187 is a single position in the genome, in or near the KALRN gene. Published research associates it with ascending aorta minimum area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs34266187 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34266187 come from?

GWAS Catalog, EBioMedicine 2022, PMID:34968759. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Ascending aorta minimum area (rs34266187). MyGeneLog™. https://www.mygenelog.com/variants/rs34266187

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