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Apolipoprotein B levels

DOCK6-AS1 · rs34243815

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 340,860 European ancestry individuals, 5,962 African ancestry individuals, 7,275 South Asian ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0293 lower (95% confidence interval 0.02-0.039); p = 3 × 10⁻¹⁰.

Where it sits Chromosome 19, band 19p13.2 — a missense change in DOCK6-AS1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Apolipoprotein B levels — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Apolipoprotein B levels.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Apolipoprotein B levels compared to the general population.

Source

Genetics of 35 blood and urine biomarkers in the UK Biobank

Sinnott-Armstrong N, Tanigawa Y, Amar D, Mars N, Benner C, Aguirre M, Venkataraman GR, Wainberg M, Ollila HM, Kiiskinen T, Havulinna AS, Pirruccello JP

and 11 more — show all

Qian J, Shcherbina A, Rodriguez F, Assimes TL, Agarwala V, Tibshirani R, Hastie T, Ripatti S, Pritchard JK, Daly MJ, Rivas MA

FinnGen

Nature genetics · 2021 · PMID 33462484 · open access

Questions about rs34243815

What is rs34243815?

rs34243815 is a single position in the genome, in or near the DOCK6-AS1 gene. Published research associates it with apolipoprotein b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs34243815 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34243815 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Apolipoprotein B levels (rs34243815). MyGeneLog™. https://www.mygenelog.com/variants/rs34243815

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