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Neutrophil percentage of granulocytes

CTD-2562J15.6 · rs34226255

Where this position leads

Condition: Blood Cell Counts

rs34226255 Condition: Blood Cell Counts Blood Cell Counts Condition rs34226255 rs34226255 CTD-2562J15.6

What the study found

Who was studied 170,672 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0251 lower (95% confidence interval 0.017-0.033); p = 4 × 10−10.

How common The G allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 19, band 19p13.11 — in an intron of KLF2-DT.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neutrophil percentage of granulocytes compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neutrophil percentage of granulocytes.
T/T Published research associates this genotype with typical/baseline likelihood of Neutrophil percentage of granulocytes — no copies of the reported risk allele.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S
and 62 more — show all
Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K, Garner SF, Grassi L, Guerrero J, Haimel M, Janssen-Megens EM, Kaan A, Kamat M, Kim B, Mandoli A, Marchini J, Martens JHA, Meacham S, Megy K, O'Connell J, Petersen R, Sharifi N, Sheard SM, Staley JR, Tuna S, van der Ent M, Walter K, Wang SY, Wheeler E, Wilder SP, Iotchkova V, Moore C, Sambrook J, Stunnenberg HG, Di Angelantonio E, Kaptoge S, Kuijpers TW, Carrillo-de-Santa-Pau E, Juan D, Rico D, Valencia A, Chen L, Ge B, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yang Y, Guigo R, Beck S, Paul DS, Pastinen T, Bujold D, Bourque G, Frontini M, Danesh J, Roberts DJ, Ouwehand WH, Butterworth AS, Soranzo N
Cell · 2016 · PMID 27863252 · open access

Questions about rs34226255

What is rs34226255?

rs34226255 is a single position in the genome, in or near the CTD-2562J15.6 gene. Published research associates it with neutrophil percentage of granulocytes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34226255 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs34226255 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34226255 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neutrophil percentage of granulocytes (rs34226255). MyGeneLog™. https://www.mygenelog.com/variants/rs34226255

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